Friday, June 02, 2006

Did I hear right?

NSAIDS (ibuprofen and diclofenac) increase the risk of heart attack in high doses. Well that's the headline but the study is about COX 2 inhibitors, that's drugs like Vioxx to you! Ibuprofen and Diclofenac (COX 1 & 2 inhibitors) are the main competitors to the newer COX 2 drugs which offer a marginally better gastro-intestinal side-effect profile, but it seems that all the Vioxx like drugs make you 42% more likely to suffer a vascular event (heart attack, or stroke). Sorry slipped into BHF language then. I mean of course a relative risk ratio of 1.42. Beginning to sound all too similar me thinks and then it is confirmed. Apparently the Ibuprofen (Nurofen) and Diclofenac (Voltarol) not only increase your risks of gastro-intestinal bleeding but have a 20%(1.2 RR) increased risk of giving you a vascular present too, but only at high dose. A Prof of whatever also introduced as BHF type on BBC news reassures us that its not too bad really. Have to way the risks and benefits apparently, only 1-5 out of 1000 or so will get a vascular event.

These new fangled drugs never get a look in with me anyway and I got stomach ulcers on the old ones so I only give them if I'm sure I'm not going to do any harm (Hippocrates). I really really hope arthritis research will attract more attention and funding as these poisonous drugs are all we've got.

But there again what does this work actually say considering the relative risk ratios are not dissimilar to much passive smoking tripe we hear about and below the magic 2 that epidemiologists strive for to even indicate an association? Its bin on the telly and the radio all f**king day......why?